Care During Chemotherapy and Beyond
(tem sir OH li mus)
Trade Name: Torisel ®
Other Name: CCI-779
is the generic name for the trade name chemotherapy
In some cases, health care professionals may use the trade name
Torisel when referring to the generic
drug name Temsirolimus.
Temsirolimus is a targeted therapy and is classified
as a mTOR inhibitor.
What Temsirolimus Is Used For:
Temsirolimus is used in the treatment of
advanced renal cell cancer
Note: If a drug has been approved for one use, physicians
may elect to use this same drug for other problems if they believe it may be helpful.
How Temsirolimus Is Given:
- Temsirolimus is given as an injection into the
vein (intravenous, IV).
- The amount of Temsirolimus that you will receive will be prescribed by your doctor
based on established dosing guidelines.
Important things to remember about the side effects
- Most people do not experience all of the
side effects listed.
- Temsirolimus side
effects are often predictable in terms of their onset and duration.
- Temsirolimus side
effects are almost always reversible and will go away after treatment is complete.
- There are many options to help minimize or prevent
Temsirolimus side effects are common (occurring
in greater than 30%) for patients taking Temsirolimus:
These are less common (occurring in about 10-29%) side
effects for patients receiving Temsirolimus:
- Shortness of breath
- Swelling in legs and feet
- Low potassium
- Abdominal pain
- Taste disturbance
- Back pain
- Weight loss
- Low white blood cell count
- Generalized aches and pains
- Chest pain
- nail disorder/thinning
- Nose bleed
- Sore throat
- Dry skin
This list includes common and less common side effects for those taking Temsirolimus.
Side effects that are very rare -- occurring in less than about 10 percent of patients
-- are not listed here. But you should always inform your health care provider if
you experience any unusual symptoms.
When to contact your doctor or health care provider:
Contact your health care provider immediately,
day or night, if you should experience any of the following symptoms:
- Fever of 100.4° F (38° C) or higher, chills (signs
of possible infection).
The following symptoms require medical attention, but
are not an emergency. Contact your health care provider within 24 hours of
noticing any of the following:
- Nausea (interferes with ability to eat and unrelieved with prescribed medication).
- Vomiting (vomiting more than 4-5 times in a 24 hour period).
- Diarrhea (4-6 episodes in a 24-hour period).
- Constipation unrelieved by laxative use.
- New or worsening abdominal pain.
- Unusual bleeding or bruising
- Black or tarry stools, or blood in your stools.
- Blood in the urine.
- Signs of infection such as redness or swelling, pain on swallowing, coughing up
mucous, or painful urination.
- Extreme fatigue (unable to carry on self-care activities).
- Mouth sores (painful redness, swelling or ulcers).
- Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst,
dry mouth, dark and decrease amount of urine, or dizziness.
Always inform your health care provider if you experience
any unusual symptoms.
- Before starting Temsirolimus treatment, make sure
you tell your doctor about any other medications you are taking (including
prescription, over-the-counter, vitamins, herbal remedies, etc.).
Do not take aspirin, products containing aspirin unless your doctor specifically
- Avoid grapefruit and grapefruit juice (may increase
the levels/adverse effects of temsirolimus).
- Do not receive any kind of immunization or vaccination
without your doctor’s approval while taking Temsirolimus. Avoid close contact
with recently vacinnated (live vaccine) individuals.
- Inform your health care professional if you are
pregnant or may be pregnant prior to starting this treatment. Pregnancy category
D (temsirolimus may be hazardous to the fetus. Women who are pregnant or become
pregnant must be advised of the potential hazard to the fetus).
- For both men and women: Use contraceptives, and
do not conceive a child (get pregnant) while taking Temsirolimus. Barrier methods
of contraception, such as condoms, are recommended.
- Do not breast feed while taking Temsirolimus.
- Drink 2 to 3 quarts of fluid every 24 hours, unless you were told to restrict your
fluid intake, and maintain good nutrition. This will decrease your chances of being
constipated, and prevent dehydration.
- You may be at risk of infection so try to avoid
crowds or people with colds, and report fever or any other signs of infection immediately
to your health care provider.
- Wash your hands often.
- To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times
a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
- Use an electric razor and a soft toothbrush to minimize bleeding.
- Avoid contact sports or activities that could cause injury.
- To reduce nausea, take anti-nausea medications as prescribed by your doctor, and
eat small, frequent meals.
- Follow regimen of anti-diarrhea medication as prescribed by your health care professional.
- Eat foods that may help reduce diarrhea (see
managing side effects - diarrhea).
- Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
- In general, drinking alcoholic beverages should be kept to a minimum or avoided
completely. You should discuss this with your doctor.
- Get plenty of rest.
- Maintain good nutrition.
- If you experience symptoms or side effects, be sure to discuss them with your health
care team. They can prescribe medications and/or offer other suggestions that are
effective in managing such problems.
Monitoring and Testing:
You will be checked regularly by your health care professional
while you are taking Temsirolimus, to monitor side effects and check your response
to therapy. Periodic blood work to monitor your complete blood count (CBC) as well
as the function of other organs (such as your kidneys and liver) will also be ordered
by your doctor.
How Temsirolimus Works:
Targeted therapy is the result of about 100 years of research dedicated
to understanding the differences between cancer cells and normal cells. To
date, cancer treatment has focused primarily on killing rapidly dividing cells because
one feature of cancer cells is that they divide rapidly. Unfortunately, some
of our normal cells divide rapidly too, causing multiple side effects.
Targeted therapy is about identifying other features
of cancer cells. Scientists look for specific differences in the cancer cells
and the normal cells. This information is used to create a targeted therapy
to attack the cancer cells without damaging the normal cells, thus leading to fewer
side effects. Each type of targeted therapy works a little bit differently
but all interfere with the ability of the cancer cell to grow, divide, repair and/or
communicate with other cells.
There are different types of targeted therapies, defined
in three broad categories. Some targeted therapies focus on the internal components
and function of the cancer cell. The targeted therapies use small molecules
that can get into the cell and disrupt the function of the cells, causing them to
die. There are several types of targeted therapy that focus on the inner parts
of the cells. Other targeted therapies target receptors that are on
the outside of the cell. Antiangiogenesis inhibitors target the
blood vessels that supply oxygen to the cells, ultimately causing the cells to starve.
Research continues to
identify which cancers may be best treated with targeted therapies and to identify
additional targets for more types of cancer.
Temsirolimus is an inhibitor of mTOR. mTOR inibition
blocks the translation of genes that regulate cancer cell proliferation. It
also results in reduced levels of certain cell growth factors involved in the development
of new blood vessels, such as vascular endothelial growth factor (VEGF).
Note: We strongly encourage you to talk with
your health care professional about your specific medical condition and treatments.
The information contained in this website is meant to be helpful and educational,
but is not a substitute for medical advice.
Chemocare.com is designed to provide the latest information about chemotherapy to patients and their families, caregivers and friends. For information about the 4th Angel Mentoring Program visit www.4thangel.org